Figure 4 | Scientific Reports

Figure 4

From: The operational model of allosteric modulation of pharmacological agonism

Figure 4

Effects of a silent allosteric modulator on the functional response to an orthosteric agonist. Effects of a pure negative (left) and positive (right) allosteric modulator on the functional response to an orthosteric agonist (top); observed half-efficient concentration EC'50 and observed maximal response E'MAX (middle); and dose ratio of half-efficient concentrations (bottom). EMAX = 1, τA = 3, values of factors of cooperativity α and β are indicated within the plots.

Back to article page