Figure 3 | Scientific Reports

Figure 3

From: The operational model of allosteric modulation of pharmacological agonism

Figure 3

Effects of a pure allosteric modulator on functional response to an orthosteric agonist. Effects of a pure negative (left) and positive (right) allosteric modulator on functional response to orthosteric agonist (top); observed half-efficient concentration EC'50 and observed maximal response E'MAX (middle); and dose ratio of half-efficient concentrations (bottom). EMAX = 1, τA = 3, values of factors of cooperativity α and β are indicated within the plots.

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