eQTL analysis of GWAS Catalog SNPs in cytokine genes. (a) Distribution of eSNPs and non-eSNPs by genomic region (upper panel). Number of GTEx associations per eSNP by genomic region (middle panel). IW-scores (K10) by genomic region (bottom panel). (b) Circos plot illustrating by chromosomal region distribution of the numbers of GWAS Catalog associations, unique GWAS Catalog SNPs, unique eSNPs, eSNP associations in the GTEx v.8 database and target genes (from the periphery to the center). (c) Spectrum of GWAS diseases associated with eSNPs in cytokine genes (frequency of association occurrence ≥ 5). (d) Results of ARCHS4 Tissues enrichment analysis for 655 target genes encoding proteins involved in protein interactions. (e) Top ten unique GO terms returned by GO enrichment analysis for the whole set of target genes. (f) Jaccard tissue similarity matrix for eQTL profiles based on matching eQTLs with their target genes and NES (Normalized effect size) direction: for the whole set of target genes (above the diagonal) and for the subset of target cytokines (under the diagonal). *(c) Ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis; (e) positive regulation of phosphate metabolic process.