Figure 2 | Scientific Reports

Figure 2

From: Cytokines mapping for tissue-specific expression, eQTLs and GWAS traits

Figure 2

Expression profiles and genome-wide eQTL data for cytokines. The tissues are shown by abbreviations (Supplementary Table S2) and grouped by tissue categories (used throughout). (a) Gene expression profiles, built from TPM (Transcripts Per Million). (b) Spearman’s rank correlation matrix of tissue gene expression (heatmap). (c) Distribution of Tau (tissue specificity) scores. (d) Tissue-specific genes (Tau ≥ 0.8, TSI (Tissue Specificity Index) ≥ 0.3) with the highest levels of expression in corresponding tissues. Circles colored in accordance with the legend for tissue categories show TPM value for the tissue(s) with the highest level of expression for a given gene. Mean ± SD for TPM values across all tissues for a gene of interest is colored in red. Grey circles represent TPM values for a given gene in other tissues. Thirteen tissues from different brain regions are signed with a common label ‘BRAIN’. (e) Manhattan plot with the number of associations for eQTLs (Y-axis) targeting cytokines. Top ten genes are signed (upper panel). Manhattan plot with the number of eQTLs (Y-axis) for cytokines. Top ten genes are signed (bottom panel). (f) A density plot showing the distribution of the number of eQTLs per gene in the set of tissue-specific genes and in the set of ‘other’ genes.

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