Figure 4 | Scientific Reports

Figure 4

From: Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial

Figure 4

Transcriptome profiles of peripheral blood mononuclear cells at week 4. (A) Hierarchical clustering analysis of DEGs (B) Top 5 biological functional categories were discovered within DEGs by IPA. Statistical significance was calculated by the Fisher’s exact test and noted as a log (P-value). (C) Heat maps of expression levels of key genes related to toll like receptor and NF-κB signaling (D) HW group (n = 3) presented the lower expression levels in IL6R and NF-κB responsive genes including IL1B, IL8 and TNFRSF10B, compared with PW group (n = 3). Data are presented as means ± SEMs. Significant differences between PW and HW groups were determined with the use of an unpaired t test. PW, plain water; HW, H2-rich water; DEG, differentially expressed genes; IPA, Ingenuity Pathway Analysis; RPKM, reads per kilobase million.

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