Table 2 Results from vaccinations of two varieties of commercial chickens with inactivated vaccines against homologous and heterologous HPAI.

From: Protection of layers and breeders against homologous or heterologous HPAIv by vaccines from Korean national antigen bank

Chicken species (age)Vaccine strain (antigen dosea)Challenge StrainbSurvival (%) (MDT)cPeak shedding (3 dpi)dHI titer (log2)e
OPCLPre-challengePost-challenge
Layer chickens (35w)rgKA435/2.3.2.1c (one dose)KA435100 (−)3/10 (0.4)2/10 (0.4)10/10(7.0)10/10(9.5)
ES270 (6.3)4/10 (0.7)1/10 (0.4)10/10(2.4)7/7(5.9)
ShamKA4350 (3.2)5/6 (3.2)3/6 (2.5)0/10(−)0/0(−)
rgES2/2.3.4.4c (one dose)ES2100 (−)1/10 (0.2)1/10 (0.1)10/10(7.2)10/10(8.7)
KA43580 (8.5)2/10 (0.3)0/10 (−)10/10(2.3)8/8(5.6)
ShamES20 (4.0)3/4 (1.4)3/4 (2.7)0/10(−)0/0(−)
Breeder chickens (35w)rgKA435/2.3.2.1c (one dose)KA435100 (−)1/8 (0.2)0/8 (−)8/8(7.1)8/8(8.6)
ES262.5 (4.7)7/8 (1.3)3/8 (0.7)8/8(3.4)5/5(6.4)
ShamKA4350 (3.4)3/3 (3.7)3/3 (3.3)0/8(−)0/0(−)
rgES2/2.3.4.4c (one dose)ES2100 (−)2/8 (0.3)0/8 (−)8/8(7.3)8/8(8.6)
KA43575 (7.0)7/8 (1.5)1/8 (0.2)8/8(3.1)6/6(7.3)
ShamES21003/4 (2.9)3/4 (1.4)0/8(−)0/0(−)
  1. aOne dose (1) contained 512 HAU (hemagglutination units).
  2. bHomologous: same as vaccine strain; heterologous: different from vaccine strain.
  3. cMDT = mean death time (days).
  4. dNo. virus positive/total in group (mean shed-virus titer).
  5. eNo. serology positive/total survived in group (mean HI titer).
  6. No. of commercial chickens: 10 layer chickens per group; 8 breeder chickens per group
  7. Abbreviations: EID50, 50% egg infectious dose; HA, hemagglutination activity; NT, not tested; dpi, days post-infection; OP, oropharyngeal; CL, cloacal; HI, hemagglutination inhibition; PD50, 50% protective dose.