Table 1 Results from vaccinations of two varieties of commercial chickens with varying doses of inactivated vaccines against HPAI.

From: Protection of layers and breeders against homologous or heterologous HPAIv by vaccines from Korean national antigen bank

VaccinesChicken species (age)Antigen DoseaSurvival(%) (MDT)bMorbidityPeak shedding (3 dpi)cHI titer(log2)dPD50
OPCLPre-challenge (Homo)Post-challenge (Homo)
rgKA435/2.3.2.1cLayer chickens (35w)1100 1/10 (0.1)0/10 (−)10/10 (7.5)10/10 (8.7)100
1/1080 (7.5) 6/10 (1.2)2/10 (0.3)10/10 (6.0)10/10 (7.6)
1/10070 (5.7)Mild depression, green diarrhea6/9 (1.3)2/9 (0.3)2/10 (3.3)5/10 (7.1)
Sham0 (3.1)Lethargy, mortality1/1 (3)1/1 (3.3)0/10 (−)NT
Breeder chickens (35w)1100 0/8 (−)0/8 (−)8/8 (7.2)8/8 (8.5)63
1/10100 2/8 (0.4)0/8 (−)8/8 (6.5)8/8 (7.6)
1/10037.5 (4.6)Mild depression, green diarrhea, mortality8/8 (2.1)7/8 (2.2)5/8 (2.4)3/3 (7.3)
Sham0 (3)Lethargy, mortalityNTNT0/8 (−)NT
rgES2/ 2.3.4.4cLayer chickens (35w)1100 0/10 (−)0/10 (−)10/10 (8.5)10/10 (9.6)350
1/10100 1/10 (0.1)0/10 (−)10/10 (6.9)10/10 (8.0)
1/100100Mild depression0/10 (−)0/10 (−)7/10 (5.0)10/10 (7.4)
Sham0 (3.8)Lethargy, mortality7/7 (4.3)6/7 (2.2)0/10 (−)NT
Breeder chickens (35w)1100 0/8 (−)0/8 (−)8/8 (7.5)8/8 (8.3)215
1/10100 2/8 (0.7)0/8 (−)8/8 (7.1)8/8 (8.0)
1/10075 (6.5)Depression, green diarrhea, mortality2/8 (0.7)1/8 (0.3)8/8 (4.8)5/5 (6.6)
Sham0 (2.9)Lethargy, mortalityNTNT0/8 (−)NT
  1. aOne dose (1) contained 512 HAU (hemagglutination units).
  2. bMDT = mean death time (days).
  3. cNo. virus positive/total in group (mean shed-virus titer).
  4. dNo. serology positive/total surviving in group (mean HI titer).
  5. No. of commercial chicken: 10 layer chickens per group; 8 breeder chickens per group
  6. Abbreviations: EID50, 50% egg infectious dose; HA, hemagglutination activity; NT, not tested; dpi, days post-infection; OP, oropharyngeal; CL, cloacal; HI, hemagglutination inhibition; PD50, 50% protective dose.