Figure 6 | Scientific Reports

Figure 6

From: Formation of an electrical coupling between differentiating cardiomyocytes

Figure 6

Comparison of the conductivity structure for transferred samples. (A) Amplitude and activation maps of transferred samples. The left side shows a typical structure of a sample transferred before the 20th day of differentiation, in the right - the sample transferred after the 20th day of differentiation. In the lower left corner, the activation maps of the excitation wave for the samples are shown. (B) Immunocytochemistry of different tissue fragments of transferred samples. The top figure is depth coding DAPI. The bottom figure is cx43. This images show three different typical cases (on the left - the presence of developed conductive pathways between cell clusters, in the middle – minimal presence of conductive pathways, and on the right – absence of any conductive pathways between the clusters). The presence and absence of possible conductive pathways between the clusters is indicated by arrows. (C) Determination of the tissues’ fractal dimension of the Hausdorff box-counting method. Red color indicates samples transplanted before 20 days, and green - after. (D) Comparison of the ratio of perimeter (L(δ)) and area (A(δ)) of tissue sites between samples transplanted before the 20th day of differentiation and after (δ – standard size). ***p-value < 0.05 (p = 0.012526, n = 5 in both groups).

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