Correction to: Scientific Reports https://doi.org/10.1038/s41598-020-58362-3, published online 30 January 2020
In Figure 5A, the chemical structure is incorrect. As a result, the Figure legend,
“AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model.
(A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.”
should read:
“AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model.
(A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthesized according to literature procedures37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.”
The correct Figure 5 and its accompanying legend appear below as Figure 1.
AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model. (A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthesized according to literature procedures37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.
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Thézénas, ML., De Leo, B., Laux-Biehlmann, A. et al. Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep 10, 5665 (2020). https://doi.org/10.1038/s41598-020-62492-z
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DOI: https://doi.org/10.1038/s41598-020-62492-z
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