Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-55886-1, published online 18 December 2019
This Article contains a typographical error in the figure legend for Figure 5.
“Correlation between pKa values of compounds with antinociception and side effects. (A,B) Antinociceptive effects as net AUC(4–12 μg/kg) of PPT (negative values result from subtraction of pre-CFA baseline PPT) at 15 min after i.v. injection of NFEPP, FF3, FF6 and Fen in inflamed (A) and contralateral, noninflamed (B) paws. AUC values were derived from curves generated by use of n = 9 (NFEPP and FF3 from3,15), n = 8–10 (FF6, see also Fig. 3) and n = 19 (Fen) animals. (C) Constipation, as assessed by number of fecal boli 1 h after s.c. injection of agonists (30 μg/kg) in relation to the pKa of the substance. Maximum and minimum numbers (with 95% confidence intervals) of boli in controls (vehicle-treated) are shown by the dashed line. Fen (n = 30) and controls (n = 34) (always included in all experiments) are averaged across all experiments; NFEPP (n = 11); FF3 (n = 12); FF6 (n = 10). (D) Locomotor activity as assessed by the total distance travelled during 30 min after s.c. injection of agonists (30 μg/kg) in relation to the pKa of the substance. Maximum and minimum travelled distances (with 95% CI) in controls (vehicle-treated) are shown by the dashed line. Fen (n = 31) and controls (n = 34) (always included in all experiments) are averaged across all experiments; NFEPP (n = 10); FF3 (n = 12); FF6 (n = 10). Graphs show means ± SEM (where available).”
should read:
“Correlation between pKa values of compounds with antinociception and side effects. (A,B) Antinociceptive effects as net AUC(4–12 μg/kg) of PPT (negative values result from subtraction of pre-CFA baseline PPT) at 15 min after i.v. injection of NFEPP, FF3, FF6 and Fen in inflamed (A) and contralateral, noninflamed (B) paws. AUC values were derived from curves generated by use of n = 9 (NFEPP and FF3 from3,15), n = 8–10 (FF6, see also Fig. 3) and n = 19 (Fen) animals. (C) Constipation, as assessed by number of fecal boli 1 h after s.c. injection of agonists (30 μg/kg) in relation to the pKa of the substance. The dashed line represents vehicle-treated controls (mean of 3 independent experiments). Fen (n = 30) and controls (n = 34) (always included in all experiments) are averaged across all experiments; NFEPP (n = 11); FF3 (n = 12); FF6 (n = 10). (D) Locomotor activity as assessed by the total distance travelled during 30 min after s.c. injection of agonists (30 μg/kg) in relation to the pKa of the substance. The dashed line represents vehicle-treated controls (mean of 3 independent experiments). Fen (n = 31) and controls (n = 34) (always included in all experiments) are averaged across all experiments; NFEPP (n = 10); FF3 (n = 12); FF6 (n = 10). Graphs show means ± SEM (where available).”
Additionally, the Article contains errors in Reference 12 which was incorrectly given as:
Sun J., Chen S. R., Chen H., Pan H. L. mu-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol (2018)
The correct reference is listed below as ref. 1.
Reference
Sun, J., Chen, S. R., Chen, H. & Pan, H. L. mu-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol 597, 1661–1675 (2018).
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Del Vecchio, G., Labuz, D., Temp, J. et al. Author Correction: pKa of opioid ligands as a discriminating factor for side effects. Sci Rep 10, 4366 (2020). https://doi.org/10.1038/s41598-020-61224-7
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DOI: https://doi.org/10.1038/s41598-020-61224-7
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