Table 3 Predicted GO terms for all genes in the “saddlebrown” module of the glioma dataset.

From: Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations

Term Average Z-Score Description Genes in Module Predicted for GO Term Total Number of Human Genes Annotated to GO Term
GO:0022010 7.58 central nervous system myelination 24 33
GO:0032291 5.47 axon ensheathment in central nervous system 24 33
GO:0016188 5.33 synaptic vesicle maturation 12 24
GO:0006559 6.09 L-phenylalanine catabolic process 12 23
GO:1902222 6.15 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process 11 23
GO:0035641 5.40 locomotory exploration behavior 9 25
GO:0030497 6.24 fatty acid elongation 8 25
GO:0048172 5.20 regulation of short-term neuronal synaptic plasticity 7 27
GO:0071625 4.75 vocalization behavior 6 30
GO:0006558 6.36 L-phenylalanine metabolic process 6 11
GO:1902221 6.15 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 6 21
GO:2000463 4.78 positive regulation of excitatory postsynaptic potential 5 35
GO:0008366 5.46 axon ensheathment 5 145
  1. ARCHS4 predictions were generated for each gene and the top five, ranked by z-score, were selected as possible annotations. Central nervous system myelination and phenylalanine catabolic process were predicted for 24 and 12 of the genes, respectively.