Figure 1 | Scientific Reports

Figure 1

From: Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations

Figure 1

(a) Density of PubMed IDs (PMIDs) per gene for all prognostic unfavorable genes in various types of cancer from the Human Protein Atlas; the bulk of genes have few articles and the density begins to decrease sharply at 100. Genes with ≤50 PMIDs are defined as functionally enigmatic genes; and genes with number of PMIDs >50 are considered well-studied genes. (b,c) Distribution of autosomal dominant and recessive disease associations among functionally enigmatic genes and well-studied genes. (d,e) Distribution of primate-specific genes and conserved eukaryotic genes among functionally enigmatic genes and well-studied genes.

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