Potential roles of JAK3 in melanoma progression. (a) The mRNA expression levels of JAK3 in WM-115, WM-266-4, IGR-39, and IGR-37 cell lines from CCLE database. (b) Kaplan-Meier plot showing the relationship between the mRNA expression levels of JAK3 gene and the overall survival of melanoma patients. The data were retrieved from TCGA database and analyzed using OncoLnc (http://www.oncolnc.org/). (c,d) The mRNA expression levels of JAK3 are down-regulated in metastatic melanoma tissues and cells relative to primary melanoma tissues and cells. Primary and metastatic melanoma patients in the GSE8401 dataset (c) and cells in the CCLE database (d) were employed for analysis. The displayed boxes contain the interquartile levels or z-scores of mRNA of JAK3 gene obtained from patients and cells. Shown by the whiskers extending outside of the box are the maximum and minimum mRNA level or z-scores of JAK3 expression from patients and cells.