Table 3 Node divergence estimates for the Lisboa3 and Q1 clades along with some of its sub-branches, including drug resistance associated with node and respective mutational profiles.

From: Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal

Clade/NodeNo. of Isolates DetectedNode Age Mean95% HPD IntervalIntra-clade Median SNP DistanceResistance AssociatedNode Mutational Profile
Lisboa3721950.01940.0–1964.523  
MDR1241974.51956.1–1990.011MDR/XDRinhA:C-15T/S94A; rpoB:S450L; rpsL:K43R
MDR2251972.91947.6–1993.610MDR/XDRinhA:C-15T/S94A; rpoB:S450L; rpsL:K43R
Lisboa3-A71981.81968.7–1991.86MDRinhA:C-15T/S94A; rpoB:D435V; rpsL:K43R
XDR1171987.81978.1–1995.88XDRgyrA:S91P; eis:G-10A
XDR2211990.41979.1–2000.39XDRgyrA:D94G; eis:G-10A
Q1351968.11942.1–1989.310  
MDR341976.51954.6–1994.910MDR/XDRinhA:C-15T/I194T; rpoB:S450L; gidB:A80P
XDR151994.31983.5–2003.05XDRgyrA:D94G; rrs:A1401G