Table 2 Longitudinal effects of a single high dose of psilocybin on brain response to high conflict trials in the emotional conflict Stroop task.

From: Emotions and brain function are altered up to one month after a single high dose of psilocybin

ContrastAnatomical Regionx, y, zkTZ
[CI > CC: 1 week] > [CI > CC: baseline]L. dorsal lateral prefrontal cortex32, 48, 122210.884.78
R. medial orbitofrontal cortex−14, 30, −124010.74.75
[CI > CC: 1 month] > [CI > CC: baseline]R. postcentral gyrus46, −22, 38408.454.49
R. fusiform gyrus34, −60, −8227.694.31
[CI > CC: 1 week] > [CI > CC: 1 month]L. inferior frontal gyrus (pars triangularis)−42, 20, 241147.944.23
L. anterior insula−36, 14, −12527.434.11
L. inferior frontal gyrus (pars opercularis)−56, 12, 22238.234.29
L. supplementary motor area−6, 12, 56826.463.85
L. premotor area−28, 6, 46215.53.55
L. inferior parietal lobule−40, −54, 40346.143.76
L. fusiform gyrus−40, −46, −24675.793.65
L. fusiform gyrus−40, −54, −14337.044.01
R. fusiform gyrus34, −50, −22276.693.92
  1. Significant clusters from whole-brain voxel-wise contrasts for high-demand incongruent (CI) greater than low-demand congruent (CC) trials [CI > CC], compared between 1 week and baseline ([CI > CC: 1 week] > [CI > CC: baseline]), and 1 week and 1 month ([CI > CC: 1 week] > [CI > CC: 1 month]) were thresholded at p(unc) < 0.0005, k ≥ 20. L: left; R: right; x, y, z: coordinates of the peak voxel in each cluster; k: cluster size. Anatomical regions for each cluster were determined using the SPM Anatomy Toolbox and the Duvernoy Brain Atlas. Whole-brain analyses were thresholded at p < 0.0005 (uncorrected), with cluster-forming threshold of p < 0.05 (uncorrected).