Effects of psilocybin on edge-wise and network-based static functional connectivity. (A) Static functional connectivity is shown for all pairwise functional connections (268 nodes × 268 nodes = 35,778 edges) at each time point. Each row and each column represents a single node (ROI) as defined by the Shen 268-node functional brain atlas56. The color of each off-diagonal cell in the connectome matrix represents the Pearson correlation value (r) for each edge (between the given nodes) in the brain. Nodes are grouped together in rows and columns by network as defined in the Shen atlas, with black lines marking the border between networks in the matrix. (B) Differences in static functional connectivity are shown within and between canonical networks for 1 Week > Baseline, 1 Month > Baseline, and 1 Week > 1 Month. Each row and column represents a single brain network as defined by the Shen 268-node functional brain atlas56. The diagonal cells represent differences in within-network connectivity between time points, and off-diagonal cells represent differences in between-network connectivity between time points. MF = medial frontal network, FP = frontoparietal network, DM = default mode network, SubC = subcortical-cerebellum network (including the salience network), SM = somatosensory-motor network, MedV = medial visual network, OccP = occipital pole network, and LatV = lateral visual network.