Table 2 Logistic regression analysis with odds ratios for the demographical, clinical & laboratory parameters of SCA patients with ACS and without ACS.

From: Predictors of impending acute chest syndrome in patients with sickle cell anaemia

ParametersOdds Ratio95% CIP value
Demography
Age1.0870.9781.2080.123
Sex (Male)1.1350.4253.0320.8
Clinical Features:
Prior ACS1.0670.6151.8510.753
HU therapy1.1090.6052.0320.658
Chest/Back pain,3.0740.89910.680.074
Fever [>37.80°C],3.9651.31611.850.014
Cough,1.6900.6094.7420.321
Tachycardia [>100],1.3660.6782.7740.389
Hypotension [<80],1.0130.9881.0390.098
Tachypnea [>25],4.2260.89619.740.068
Reduced pulse oximetry
O2 saturation [<95],8.1112.68924.470.000
Asplenia,7.0491.95718.680.000
Laboratory Parameters:
Median Hb basal,0.8030.5551.1610.244
Median Hb nadir,0.5350.3850.8050.003
Median WBC count basal,1.1750.9911.3930.064
Median WBC count max,1.2361.0981.3920.000
Median platelet count basal,1.0020.9981.0050.353
Median platelet count nadir,0.9990.9961.0020.438
Median retic count,1.1900.8971.5790.229
Median basal HbF,0.9830.8751.0600.439
S.LDH at admission,1.0021.0001.0040.132
S.LDH max,1.0011.0001.0030.107
CRP at admission1.0000.9941.0070.964
CRP max1.0051.0001.0100.071
AST, u/L1.0240.9951.0540.103
ALT, u/L1.0100.9901.0310.331
S. bilirubin,1.0240.9981.0510.069
Interventions:
Simple blood transfusions,8.5142.31031.3750.001
Exchange blood transfusions,31.5714.031247.260.001
  1. Key: HU- hydroxyurea, ACS- acute chest syndrome, Hb- Haemoglobin, WBC- white blood cell count, NIV- non-invasive ventilation, LDH-lactic dehydrogenase, CRP- C-reactive protein, AST- aspartate transaminase, ALT- alanine transaminase.