Figure 1 | Scientific Reports

Figure 1

From: Signalling architectures can prevent cancer evolution

Figure 1

Mechanisms preventing cancer formation. A costly diffusive signal, for example, a growth factor, can regulate the expression of several genes. To generate an effect equivalent to the action of the diffusive signal a particular set of genes have to exhibit a particular expression pattern. As suggested by the multistage theory, this involves a hard-to-evolve, cryptic solution where several mutations are required to produce the particular pattern of gene expression involving a set of stages where the expression of each gene G1, G2 …, G6 should be modified, and that will trigger uncontrolled cell division.

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