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Figure 1

From: Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension

Figure 1

Assessment of hypoxia-induced pulmonary vascular disease. (A) Pulmonary hypertension developing during hypoxia in 8–10 week old male and female WT (closed black circles) and SOD3KO (KO) (red open circles) mice, determined by closed chest RV puncture. (B) Right ventricular hypertrophy developing during hypoxia, defined by Fulton’s index RV/(LV + S) mass ratio. Some RVSP measurements were excluded based on predefined criteria for heart rate and end-diastolic pressure. Data expressed as mean ± SEM. *p < 0.05 **p < 0.01 by 2-way ANOVA.

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