Table 1 Selected examples of known domains-swapped protein structures.

From: Passenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein

 interface area, Å2ΔiG kcal/molhydrogen bondssalt bridgesdi-sulphide bonds
MBPeng-KFLFAK11228−174.515970
MBPeng-KFLPYK211322−164.517770
LeuA (1sr9)7646−53.199390
prion (1i4m)3119−57.32862
cystatin Ca (1tij)3096−39.258130
cystatin Cd (1g96)2844−38.450100
suc1 (1sce)2163−26.83060
RNaseA (1a2w)1932−14.33530
GB1 (1Q10)1762−33.51800
  1. Values were calculated by the ‘Protein interfaces, surfaces and assemblies service PISA at the European Bioinformatics Institute32. ΔiG: calculated solvation free energy gain upon formation of the interface.
  2. LeuA: Mycobacterium tuberculosis LeuA.
  3. hPrion: domain-swapped dimer of the human prion protein.
  4. cystatin Ca: 3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets.
  5. cystatin Cd: 3D domain-swapped dimeric human cystatin C.
  6. Suc1: domain-swapped dimer of the cell cycle-regulatory protein suc1.
  7. RNaseA: N-terminal domain-swapped dimer of bovine RNase A.
  8. GB1: domain-swapped dimeric mutant of the B1 domain of Streptococcal protein G.