Figure 4 | Scientific Reports

Figure 4

From: Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization

Figure 4

Linkage disequilibrium across the CYP2B11 gene. Results of genotype association analysis conducted using the Haploview program40. Shown are the locations of polymorphic sites identified in the 5′-enhancer, exons 1 to 9, and 3′UTR in 13 Greyhounds (a) and single dogs sampled from 45 different breeds (b). Below each set of polymorphisms are matrices of linkage disequilibrium r2 values (as a percent) for pairwise comparisons. All black squares indicate complete linkage (r2 = 100%). c.1952 C/T (#4) was not associated (r2 = 0%) with any other polymorphism genotyped in both Greyhounds and non-Greyhound dogs. c.2498 G/T (#8) was invariant in all Greyhounds genotyped. The genetic polymorphism labels used here (#1 to #9) correspond to the labels used in Tables 2 and 3. Samples from Greyhound dogs were identified by their owners as dogs registered with the National Greyhound Association bred for racing.

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