Efficacy and biocompatibility of DOX@CELVEC. (A) Whole body longitudinal non-invasive bioluminescent imaging of mice at 0, 7, and 14 days following inoculation with an LL/2 lung tumor model and administration of PBS (CTRL), DOX, or DOX@CELVEC every other day. (B) Quantitative assessment of total bioluminescent signal observed from tumor growth at 4, 7, 10, and 14 days post-treatment (top). Further comparison of relative flux normalized to CTRL was performed at 4 d (bottom). (C) Histological evaluation of lung, liver, and spleen following 24 h treatment with PBS (CTRL, left column), DOX (middle column) and DOX@CELVEC (right column). Scale bar, 200 μm. The data is plotted as mean ± SEM. *<0.05; **p < 0.01; ****p < 0.0001.