Schematic representation of CELVEC. CELVEC generated using leukocytes isolated from whole blood or grown using cell culture. Following purification, cells are loaded with a chemotherapeutic payload using electroporation. Once administered intravenously into a mouse model, CELVECs accumulate within the pulmonary environment or lungs. Payload is passively released within the first several hours of accumulation in a controlled fashion, following by CELVEC sequestration and degradation in the spleen and liver.