Figure 4 | Scientific Reports

Figure 4

From: The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis

Figure 4

(A) Association of MS risk SNP rs7260482 genotype with expression of proximal gene PVR, and EBV miRNAs (B) BART3-5p and (C) BART4-3p. Correlation of EBV DNA copy number with (D) PVR, (E) BART3-5p and (F) BART4-3p expression levels. (G-I) Correlation between PVR, BART3-5p and BART4-3p expression levels. PP - protective homozygous, PR - heterozygote genotype, RR - risk homozygous SNP genotype. The genotype association with expression was calculated through testing the differences in the expression level in PP, PR and RR genotypes using the linear model test. Correlations were tested using Spearman’s Rank-Order correlation test.

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