Figure 1 | Scientific Reports

Figure 1

From: Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery

Figure 1

(a) Structure of HIRMAb-LC-LL-HEXA, where the HEXA enzyme is fused to the CT of the light chain (LC) of the HIRMAb via a 31-amino acid long linker (LL). (b) Structure of HIRMAb-HC-LL-PPT1, where the PPT1 enzyme is fused to the CT of the heavy chain (HC) of the HIRMAb via the LL linker. (c) Structure of HIRMAb-LC-LL-ASM, where the ASM enzyme is fused to the CT of the LC of the HIRMAb via the LL linker. (d) Structure of HIRMAb-HC-LL-GLB1, where the GLB1 enzyme is fused to the CT of the HC of the HIRMAb via the LL linker. VH = variable region of HC; VL = variable region of LC; CL = constant region of LC; CH1, CH2, and CH3 are domains of the constant region of the HC.

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