Figure 5 | Scientific Reports

Figure 5

From: Essential role of the initial activation signal in isotype selection upon deletion of a transcriptionally committed promoter

Figure 5

Differential induction of switch transcription in response to LIT and CIT. (AF) RT-qPCR quantification of Sγ2b (A), Sα (B), Sγ2a (C), Sγ3 (D), Sγ1 (E), and Sε (F) pre-switch transcripts levels in CH12 cells and Iα-deleted clones 3, 5 and 8 following LIT or CIT stimulation. Transcripts levels in splenic B cells activated with LIT and CIT for Sγ2b (A) and Sα (B), and with LPS + IL4 (LI), LIT and CIT for Sγ1 and Sε (E,F) are boxed (n ≥ 3).

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