Integration of multiple inputs is mediated by gain control of the GP-EP synapse. GP inputs are labeled red or blue for neurons increasing or decreasing their firing rate, respectively. (A) Raster plot of the activity of 10 simulated GP neurons that increase (i) or decrease (ii) their firing rate for 200 ms. In these examples the baseline firing rate of all neurons was 20 Hz and the gain was set to 3 (i) or 1/3 (ii). (B) Predicted membrane potential of an EP neuron that receives input from 10 GP neurons in (A). (C) Predicted change in membrane potential as a function of the multiplication factor, calculated for baseline frequencies of 10, 40 and 60 Hz. (D) Predicted change in membrane potential as a function of the multiplication factor and the baseline firing rate.