Figure 1 | Scientific Reports

Figure 1

From: Short-term depression shapes information transmission in a constitutively active GABAergic synapse

Figure 1

Simulation of GP-EP synapses. (A) Experimental design. Illustration of a sagittal brain slice containing the GP and EP. A stimulation electrode was positioned in the GP and whole cell recordings were obtained from EP neurons. A confocal image shows two biocytin filled EP neurons (scale bar = 25 μm). (B) Whole-cell voltage-clamp recording displaying the response of an EP neuron to stimulation of the GP at 10 Hz. (C) Enlargement of the first evoked IPSC in B. Red curve shows fit of an alpha function (Eq. 6) with a \({\tau }_{dec}\) of 12 ms. (D) simulated traces of GP evoked IPSPs induced by activation of the synapse at 5, 10, 20 and 40 Hz. (E) normalized IPSP amplitude evoked by each activation of the simulated GP synapse at different frequencies. (F) steady-state depression as a function of the time interval between pulses. Black traces represent population average of the IPSP amplitude evoked by each pulse recorded during GP stimulation at different frequencies. Means ± SEM. Red traces represent data from the simulation.

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