Effect of meal timing on the PK parameters of PB in patients with normal-GGT PFIC. The Cmax (a), AUC0–4 (b), Tmax (c), kel (d), and t1/2 (e) values of PB were calculated as described in the Methods. The plots represent these parameters for individual patients; the points representing the same patient are connected to one another by lines. The horizontal line in each column indicates the mean values. BF, breakfast. *P < 0.05; **P < 0.01; ***P < 0.001 vs just after BF.