Figure 5 | Scientific Reports

Figure 5

From: Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders

Figure 5

Effects of Shmt2 knockout on taurine, purine, and pyrimidine metabolism in livers and brains from E13.5 embryos. (a) A scheme of taurine metabolism in livers of Shmt2-knockout E13.5 embryos. (b) Effects of Shmt2 knockout on the concentrations of metabolites included in taurine metabolism on the livers or brains from E13.5 embryos. (c) A scheme of purine metabolism in livers of Shmt2-knockout E13.5 embryos. (d) Effects of Shmt2 knockout on the concentrations of metabolites included in purine metabolism on livers or brains from E13.5 embryos. (e) A scheme of pyrimidine metabolism in livers of Shmt2-knockout E13.5 embryos. (f) Effects of Shmt2 knockout on the concentrations of metabolites included in pyrimidine metabolism on livers or brains from E13.5 embryos. Red characters denote metabolites that increased; blue characters denote metabolites that decreased; black characters denote metabolites unchanged in foetal liver without functional Shmt2; and grey characters denote metabolites not quantified in this study. WT, wild-type foetal livers (solid blue bars) and wild-type foetal brains (open blue bars); KO, Shmt2-knockout foetal livers (solid red bars) and Shmt2-knockout foetal brains (open red bars). Data represent the mean ± S.D. *P < 0.05; **P < 0.01, ***P < 0.001 (WT, n = 5; KO, n = 5).

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