Figure 1 | Scientific Reports

Figure 1

From: C. elegans protein interaction network analysis probes RNAi validated pro-longevity effect of nhr-6, a human homolog of tumor suppressor Nr4a1

Figure 1

Protein-protein interaction network. (a) Venn diagram showing overlap between aging network and tumor supressor gene (TSG) network. Combined network is splitted into clusters. (b) Number of genes into each cluster. (c) Protein-protein interaction network of aging and human tumor supressor gene orthologs of C. elegans. Only the primary connectors of nhr-6 are highlighted. The annotation of the nodes can be accessed from the XGMML (extensible graph markup and modelling language) network Supplementary File 1. Network is organized into eight clusters. Cluster1 - proteins associated with aging. Cluster2- proteins exclusively interacts with aging proteins but not with the TSG orthologs. Cluster3- connector proteins annotated to be involved in aging. Cluster4- proteins included exclusively in intersection of aging and TSG network but connectors are annotated as both aging and TSG. Cluster5- proteins included exclusively in intersection of aging and TSG network but conntectors are not annotated as aging or TSG. Cluster6- connector proteins annotated as human TSG orthologs. Cluster 7- proteins exclusively interacts with tumor supressor proteins but not with the aging associated proteins. Cluster8- proteins associated with tumor supression.

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