Author Correction: Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK

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Correction to: Scientific Reports, published online 08 August 2019

In Figure 9A, the connection between S6K1 and Rictor was switched with that between Rictor and mTORC2. The correct Figure 9 appears below as Figure 1.

Figure 1

Summary of our model on the molecular action of YM155 in prostate cancer cells. Panel A represents the overall molecular steps in which our model supports that YM155 rapidly promotes the activation of AMPK and subsequent inactivation of mTORC1 and suppression of cap-dependent translation of proteins involved in cell cycle and survival. This model also illustrates that YM155 additionally promotes the loss of AMPKα1 or AMPKα2, and that such loss counter-intuitively promotes growth arrest and cell death. Panel B is a simplified version of panel A.

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Correspondence to David Danielpour.

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