Figure 5 | Scientific Reports

Figure 5

From: Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η

Figure 5

A possible model of the processing of an embedded ribonucleotide and ribonucleotide-induced mutagenesis. 8-Oxo-rG could be generated by the incorporation of oxidized ribonucleoside triphosphates into DNA or by the oxidation of the embedded ribonucleotides. RNase H2 and BER cannot remove 8-oxo-rG21,22. NER is involved in the excision of such a damaged ribonucleotide. Alternatively, Pol η can bypass 8-oxo-rG to suppress the mutagenic events induced by the embedded ribonucleotide. The unrepaired ribonucleotide is subject to Top1-mediated processing, leading to the deleterious mutations.

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