Table 2 Comparisons of individual retinal layer thickness in the foveal and 4 perifoveal region measured by the automated segmentation of the Spectralis optical coherence tomography after ocular magnification adjustment.

From: Comparison of Individual Retinal Layer Thicknesses between Highly Myopic Eyes and Normal Control Eyes Using Retinal Layer Segmentation Analysis

Thickness Parameter All Participants
(N = 164)
Control Group
(AL < 26 mm; N = 105)
High Myopic Group (AL ≥ 26 mm; N = 59) P-value*
Total retina
Center subfield 282.4 ± 38.2 264.3 ± 30.9 315.2 ± 26.5 <0.001
Temporal subfield 339.9 ± 35.3 321.2 ± 26.7 373.8 ± 20.8 <0.001
Superior subfield 352.6 ± 36.5 333.4 ± 27.8 387.5 ± 21.2 <0.001
Nasal subfield 355.2 ± 38.5 335.5 ± 29.3 390.7 ± 25.3 <0.001
Inferior subfield 348.7 ± 37.4 329.6 ± 30.2 383.2 ± 20.7 <0.001
Retinal nerve fiber layer
Center subfield 12.3 ± 2.9 11.3 ± 2.8 14.3 ± 2.1 <0.001
Temporal subfield 18.3 ± 2.3 17.3 ± 1.7 20.1 ± 2.3 <0.001
Superior subfield 26.7 ± 5.8 24.1 ± 4.7 31.4 ± 4.5 <0.001
Nasal subfield 22.8 ± 4.8 20.9 ± 3.7 26.4 ± 4.5 <0.001
Inferior subfield 26.7 ± 6.1 24.0 ± 4.5 31.5 ± 5.7 <0.001
Ganglion cell layer
Center subfield 15.9 ± 5.7 14.0 ± 5.4 19.3 ± 4.7 <0.001
Temporal subfield 48.2 ± 9.8 43.8 ± 8.2 56.1 ± 7.1 <0.001
Superior subfield 53.5 ± 8.6 49.8 ± 7.5 60.2 ± 6.2 <0.001
Nasal subfield 52.4 ± 10.1 48.2 ± 9.0 60.2 ± 6.9 <0.001
Inferior subfield 52.3 ± 9.7 48.4 ± 9.3 59.2 ± 5.6 <0.001
Inner plexiform layer
Center subfield 21.5 ± 4.8 19.6 ± 4.3 24.8 ± 3.9 <0.001
Temporal subfield 42.2 ± 6.5 39.2 ± 5.3 47.7 ± 4.6 <0.001
Superior subfield 41.9 ± 5.8 39.2 ± 4.8 46.7 ± 4.2 <0.001
Nasal subfield 43.6 ± 6.9 40.3 ± 5.4 49.6 ± 4.8 <0.001
Inferior subfield 41.6 ± 6.2 39.0 ± 5.5 46.4 ± 4.2 <0.001
Inner nuclear layer
Center subfield 20.8 ± 6.2 19.3 ± 6.5 23.6 ± 4.7 <0.001
Temporal subfield 39.2 ± 4.9 37.4 ± 4.6 42.5 ± 3.8 <0.001
Superior subfield 42.8 ± 4.7 41.1 ± 4.6 45.8 ± 3.1 <0.001
Nasal subfield 43.0 ± 5.4 41.1 ± 5.0 46.4 ± 4.1 <0.001
Inferior subfield 42.8 ± 5.7 40.8 ± 5.2 46.6 ± 4.6 <0.001
Outer plexiform layer
Center subfield 28.8 ± 9.2 26.1 ± 7.5 33.8 ± 9.9 <0.001
Temporal subfield 35.9 ± 10.5 33.1 ± 9.5 41.0 ± 10.3 <0.001
Superior subfield 39.9 ± 12.6 37.6 ± 11.5 44.2 ± 13.4 0.001
Nasal subfield 38.6 ± 12.2 36.9 ± 10.8 41.7 ± 14.0 0.014
Inferior subfield 39.8 ± 12.0 37.1 ± 10.6 44.8 ± 12.8 <0.001
Outer nuclear layer
Center subfield 92.4 ± 15.9 87.2 ± 15.3 101.9 ± 12.3 <0.001
Temporal subfield 71.0 ± 11.9 68.3 ± 11.5 75.7 ± 11.1 <0.001
Superior subfield 64.0 ± 14.5 61.1 ± 13.6 69.1 ± 14.8 <0.001
Nasal subfield 69.2 ± 16.7 66.0 ± 15.3 75.1 ± 17.6 <0.001
Inferior subfield 61.7 ± 14.3 60.0 ± 13.7 64.6 ± 15.0 <0.001
Photoreceptors
Center subfield 74.4 ± 6.7 71.4 ± 5.9 79.9 ± 4.0 <0.001
Temporal subfield 70.1 ± 5.7 67.2 ± 4.5 75.5 ± 2.9 <0.001
Superior subfield 68.4 ± 5.4 65.5 ± 4.2 73.6 ± 2.6 <0.001
Nasal subfield 69.2 ± 5.7 66.3 ± 4.5 74.5 ± 3.6 <0.001
Inferior subfield 68.5 ± 5.5 65.5 ± 4.4 73.9 ± 2.3 <0.001
Retinal pigment epithelium
Center subfield 17.0 ± 2.8 16.2 ± 2.5 18.6 ± 2.6 <0.001
Temporal subfield 14.9 ± 1.8 14.4 ± 1.8 15.9 ± 1.4 <0.001
Superior subfield 15.9 ± 2.1 15.4 ± 2.2 16.7 ± 1.6 <0.001
Nasal subfield 15.8 ± 2.2 15.3 ± 2.1 16.7 ± 2.1 <0.001
Inferior subfield 15.2 ± 2.1 14.8 ± 2.2 16.0 ± 1.6 <0.001
  1. AL, axial length.
  2. Values are presented as mean thickness ± standard deviation; SD (µm).
  3. P values were yielded by independent student t-test between the control group (AL < 26 mm) and high myopia group (AL ≥ 26 mm).
  4. *Bold values indicate statistically significant differences (P < 0.05).