Figure 3 | Scientific Reports

Figure 3

From: Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice

Figure 3

FNPs achieve widespread delivery through the SAS within 2 hours of IT administration. (A) Sagittal view of the entire neuraxis showing distribution of FNPs (red) from the olfactory bulb to the sacral spinal cord. (B) FNPs were able to access nearly all CSF exposed tissue, including into the sulci of the cerebellum. Along the spinal column, FNPs distributed around the entire circumference of the spinal cord all the way from the cervical (C) to the sacral (D) regions. Scale bar in B = 500 µm and in C&D = 200 µm.

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