Figure 1 | Scientific Reports

Figure 1

From: Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors

Figure 1

The S1 segment in the GluN3A subunit is essential for the surface expression of GluN1/GluN3A receptors. (a) Schematic diagram of the GluN3A subunit, with the amino-terminal domain (ATD), ligand-binding domain (LBD) composed of S1 and S2 segments, and C-terminal domain (CTD) indicated; the black rectangles indicate membrane domains. (b) Representative images of total and surface GluN1-4a/GFP-GluN3A receptors lacking the indicated domains in the GluN3A subunit expressed in COS-7 cells and labelled 24 h after transfection. (c) Summary of the relative surface expression of the indicated GluN subunits measured using fluorescence microscopy (n ≥ 20 cells per group); *p < 0.05 vs. GluN1-4a/GluN3A (ANOVA).

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