Modulation of p43 signaling impairs early muscle regeneration at 28 days post injury. (A) Experimental setup. Tibialis muscle were injured by a single CTX injection and analyzed at different times following injury. (B) Assessment of muscle recovery evaluated by the ratio between the injected and contralateral tibialis weight analyzed at different times following injury (n = 6 for each group). (C) H&E staining on cryosections of uninjured and regenerating muscle tissue at 4, 10 and 28 d.p.i in wild-type, p43−/− and p43-Tg mice. Statistical significance: ***p < 0.001, Student’s t-test. Results are expressed as ± sem.