Table 6 A summary of the randomized controlled trials on the effects of aerobic exercise on asthma control.

From: Regular exercise improves asthma control in adults: A randomized controlled trial

Author, year City,
Country
Design Participants randomised Intervention programme Asthma control measures Exercise intervention group Reference group Effect of exercise intervention
França-Pinto et al.9 São Paolo, Brazil Parallel
two-arm
12-week
RCT
Outpatients, aged 20–59 yrs; moderate or severe persistent asthma:
22 in exercise intervention;
21 in reference group
Intensive aerobic training 2x per week under suprvision Asthma Control Questionnaire score Baseline score:
1.4 points (SD 1.2)
Change:
0.2
95% CI: −0.3 to 0.5
Baseline score:
1.6 points (SD 0.9)
Change:
0.1
95% CI: −2.1 to 0.5
0.2 points
95% CI: −0.3 to 0.7
P = 0.457
Freitas et al.10 São Paolo, Brazil Parallel
two-arm
12-week
RCT
Outpatients, aged 30–60 yrs; moderate or severe asthma; obese (BMI 35- < 40):
27 in exercise & weight loss;
28 in weight loss group;
Intensive aerobic training and muscle exercise 2x per week Asthma Control Questionnaire score 69% of subjects improved
Baseline score:
2.0 (95% CI: 1.4 to 2.7)
Follow-up score:
1.1 (0.4 to 1.5)
Change:
0.9 (P < 0.001)
36% subjects improved
No change between baseline and follow-up score
Difference
P = 0.03
Toennesen et al.11 Copenhagen, Denmark Parallel
four-arm
8-week
RCT
Normal weight adults, aged 18–65 yrs:
36 in exercise intervention;
38 in dietary intervention;
37 in exercise & dietary
38 in reference group
Intensive aerobic interval training 3x per week under supervision Asthma Control Questionnaire score Exercise:
Baseline score:
1.7 (SD 0.6)
Change:
0.7
Exercise & diet:
1.9 (SD 0.7)
0.9
Baseline score:
1.8 (SD 0.7)
Change:
0.3
Ex vs. Ref:
0.4 points
95% CI: −0.01 to 0.78
P = 0.06
Ex & diet vs. Ref:
0.6 points
95% CI: 0.14 to 1.02
P < 0.05
Jaakkola et al. the present study Oulu, Finland Parallel
two-arm
24-week
RCT
Adults with mild/moderate asthma, aged 16–65 yrs;
67 in exercise intervention;
64 in reference group
Personalized aerobic training 3x per week, muscle training 2x per week and stretching before and after training Asthma Control
Test score
62% of subjects improved;
Baseline score:
Median 21
(IQR 18 to 22)
Change:
1.19 points
95% CI: 0.36 to 2.02
P = 0.006
39% of subjects improved
Baseline score:
Median 22
(IQR 20 to 23)
Change:
0.45 points
95% CI: −0.22 to 1.12
P = 0.178
23.3%
95% CI: 2.7 to 43.8
P = 0.032
Crude:
0.74 points
95% CI: −0.31 to 1.78
P = 0.166
Adjusted:
3.99 points
1.32 to 6.66
P = 0.004