Figure 3 | Scientific Reports

Figure 3

From: Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer’s disease model

Figure 3

Differentially expressed circRNA–miRNA–mRNA regulatory network in the brain of Alzheimer’s disease model. For the 55 up-regulated circRNAs (red ellipses) and 23 downstream target miRNAs (blue rectangles) in 7 M brain, 242 downstream mRNAs (green diamonds) were relevantly up-regulated, consisting a total of 876 circRNA–miRNA–mRNA regulatory network (panel A). For the 46 down-regulated circRNAs and 21 downstream target miRNAs in 7 M brain, 388 downstream mRNAs were relevantly down-regulated, consisting a total of 1,399 circRNA–miRNA–mRNA regulatory network (panel B). For the 5 up-regulated circRNAs and 3 downstream target miRNAs in 12 M brain, 20 downstream mRNAs were relevantly up-regulated, consisting a total of 25 circRNA–miRNA–mRNA regulatory network (panel C). For the 7 down-regulated circRNAs and 3 downstream target miRNAs in 12 M brain, 9 downstream mRNAs were relevantly down-regulated, consisting a total of 13 circRNA–miRNA–mRNA regulatory network (panel D).

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