Microarray data analysis of the differentially expressed mRNAs and circRNAs in the brain of Alzheimer’s disease model. Scatter Plot (panel A) shows the distribution of the expression levels of mRNAs in the Alzheimer’s disease (AD) model and the control. Scatter Plot (panel B) and volcano plot (panel C) demonstrate the distribution of the expression levels of circRNAs in the AD model and the control. The green lines in scatter plot and volcano plot demark the fold change of 1.5. The X- and Y-axes in the scatter plot indicate the averaged normalized signal values of the group (log2 scaled). In the volcano plot, red squares represent the differentially expressed circRNAs (P-value < 0.05). Panel D shows hierarchical cluster analysis of differentially expressed circRNAs. The log2 signal intensity is reflected in the color scale, which runs from green (low intensity) to red (strong intensity).