Regional Plots of PRiMA1 and PTPN21. The X-axis displays the base pair location of each CV on chromosome 14; Y axis displays the –Log10 (p-values) of QTDT for association with total cIMT in the Families. The index CV is displayed as a purple diamond. The color of the circles indicates LD estimated in the families between each CV and the index CV. The solid purple line displays the estimated recombination rate. In PRiMA1 (panel A.), the index CV is rs12587586, the top marker identified in the current study. The most significant marker in the previous study (rs7152362) is not in LD (r2 = 0.02; D′ = 0.31) with rs12587586. In PTPN21, the index CV is rs2274736, the most significant CV in the region. It is located within a region with extended LD containing five genes, i.e. SPATA7, PTPN21, ZC3H14, EML5, and TTC8.