|Mean Retention Time (min)||Mycobacterial culture||Compound||Potential Cellular and Metabolic Associations|
|3.681||M. kansasii||Ethanol||Metabolized into acetyl CoA, used for energy in the citric acid cycle. Can be converted to acetaldehyde and then into acetic acid. Small amounts are endogenously produced via anaerobic fermentation43. Identified previously in MAP cultures48.|
|4.250||BCG||Benzene||Identified previously in M. tuberculosis cultures17, and MAP48,49.|
Identified in breath and feces of MAP infected goats50.|
3-pentanone and methyl isopropyl ketone are isomer43.
|Ethylbenzene||Metabolite formed during degradation of styrene40. Some mycobacterial strains have been demonstrated capable of ethylbenzene degradation51,52. Identified previously in breath samples of M. tuberculosis infected humans53.|
|11.344||M. kansasii||Styrene||M. tuberculosis is capable of degrading styrene under hypoxic conditions which may play a role in intracellular survival54. Identified previously in breath samples of M. tuberculosis infected humans53.|
|13.354||M. kansasii||Octanal||A substrate for fatty aldehyde dehydrogenase and alcohol dehydrogenase43. Mycobacteria have been shown to utilize alcohol dehydrogenases in the biosynthesis of cell envelope lipids55,56.|
By-product of ethylbenzene metabolism43|
Has been identified different concentrations in feces of white-tailed deer (Odocoileus virginianus) vaccinated with BCG or infected with M. bovis57.
|18.769||M. kansasii||Pentanedioic acid, 2,4-dimethyl, dimethyl ester; (dimethyl glutarate)|
|19.048||M. kansasii||3,3-dimethyl hexane|
|20.114||M. kansasii||Cyclohexane, isothiocyanate||Isothyocyanates are formed by enzymatic conversion of glucosinolates which are synthesized from amino acids58|