Table 3 Effects of active ingredients of TCM on plasma concentration of GA (µg/mL, n = 6).

From: A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients

mg/kg0.5 h1.0 h2.0 h3.0 h4.0 h
GA2.65 ± 2.025.08 ± 4.202.09 ± 1.912.07 ± 1.932.47 ± 1.33
GA + BB (200)4.93 ± 3.21(0.9)5.45 ± 3.08 (0.05)3.03 ± 1.51 (0.3)
GA + BB (400)4.79 ± 1.49 (0.9)3.35 ± 1.80 (0.3)3.29 ± 3.28 (0.5)
GA + CA (200)2.85 ± 0.63(0.8)2.37 ± 0.86 (0.2)1.86 ± 0.77 (0.7)
GA + CA (400)1.49 ± 0.24(0.2)2.45 ± 0.71 (0.2)2.34 ± 0.32 (0.9)
GA + KL (200)3.67 ± 1.15 (0.4)5.60 ± 2.47(0.02)3.26 ± 2.44(0.2)
GA + KL (500)4.36 ± 2.01 (0.7)4.21 ± 3.34 (0.2)3.30 ± 1.10(0.04)
  1. —, not done; Data in parentheses are actual p-values, compared to GA group; p < 0.05 was considered statistically significant.