Figure 4 | Scientific Reports

Figure 4

From: Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors

Figure 4

Connectivity Map analysis indicates CB-5083 treatment produced perturbed transcriptomic profile similar to ATPase inhibitors and protein synthesis inhibitors. (A) Similarities in perturbed transcriptomic profiles produced by CB-5083 and other compounds. (B) Similarities in perturbed transcriptomic profiles produced by CB-5083 and classes of compounds. (C) The similarity in perturbed transcriptomic profiles produced by CB-5083 and specific gene knockdown. The complete results of CMAP analysis are available at the following link: https://osf.io/uzdbw/.

Back to article page