Figure 3 | Scientific Reports

Figure 3

From: Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors

Figure 3

The number of differentially expressed transcripts with CB-5083 treatment. (A) The Venn diagram represents the number of differentially regulated transcripts in both parental and resistant cell lines upon 6 hours of treatment with CB-5083 (5 µM). Differential expression was calculated based on the false discovery rate ≤0.001 and fold change ≤1.5. (B) The table indicates the number of transcripts that are differentially regulated (upregulated and downregulated) in OVSAHO-parental and OVSAHO-R1 cells by CB-5083 treatment. (C,D) Plots represent maximum mean expression values in 19 shared transcripts that were upregulated with CB-5083 treatment in OVSAHO parental and resistant cells (C) and 11 transcripts with higher expression in resistant cells treated with CB-5083 (D). (E,F) Relative log2 fold change values of the same transcripts as shown in C and D. Each line represents a transcript.

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