Figure 1 | Scientific Reports

Figure 1

From: Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors

Figure 1

Differential regulation of pathways with CB-5083 treatment. (A) Inferred pathways upregulated by 5 µM of CB-5083 treatment in the OVSAHO parental cells. (B) Inferred pathways upregulated by 5 µM of CB-5083 treatment the resistant (OVSAHO-R1) cells. (C) Inferred pathways associated with genes downregulated by 5 µM of CB-5083 treatment in OVSAHO parental cells. (D) Inferred pathways associated with genes downregulated by 5 µM of CB-5083 treatment in the resistant (OVSAHO-R1) cells. Terms with the prefix “GO” are from the Gene Ontology Consortium, the prefix “R-HSA” from the Reactome, the prefix “M” from the Gene Set Enrichment database, and the prefix “hsa” is from the KEGG database.

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