Figure 6 | Scientific Reports

Figure 6

From: Molecular Modeling of ALK L1198F and/or G1202R Mutations to Determine Differential Crizotinib Sensitivity

Figure 6

Structural analyses on the R1202 residue in the G1202R and L1198F/G1202R mutants. In (AD), separation distance is represented by solid curves with the left-side y-axis reading and interaction count represented by dotted lines with the right-side y-axis reading. (A) Distance between R1202 Cζ atom and L1122 Cα atom in the G1202R mutant. The R1202–L1122 interaction is also counted. (B) Distance between R1202 Cζ atom and E1132 Cδ atom in the G1202R mutant. The R1202–E1132 interaction is also counted. (C) The same monitored items as in (A), but for the L1198F/G1202R mutant. (D) The same monitored items as in (B), but for the L1198F/G1202R mutant. (E) Distribution of the separation distance between R1202 Cζ and L1122 Cα atoms. (F) Distribution of the separation distance between R1202 Cζ and E1132 Cδ atoms.

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