Figure 4 | Scientific Reports

Figure 4

From: The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions

Figure 4

Effects of ICV THC and CYP on anterior NASh medium spiny neurons activity patterns. (a) Representative microphotograph showing typical intra-aNASh in vivo MSN recording location (b) Summary of experimental neuronal groups showing relative changes (no change, increase, or decrease) in firing frequencies following ICV pharmacological treatments (C) ICV THC significantly decreased spontaneous aNASh MSN neuronal firing frequency. (d) ICV THC alone (1 µg/μl) caused a significant decrease in spontaneous aNASh MSN neuronal firing frequency rates vs baseline. This inhibitory effect was reversed by co-administration of the behaviorally effective dose of CYP (10 µg/μl). (e) Sample rastergram showing typical aNASh MSN response pattern following ICV THC (1 µg/µl) infusion (arrows indicate intra-NAc infusion event). (f) Sample rastergram showing typical aNASh MSN response pattern following ICV THC (1 µg/µl) and CYP (10 µg/µl) infusion, demonstrating the block of THC’s neuronal effects with MOR blockade (arrows indicate intra-NAc infusion event).

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