Figure 5 | Scientific Reports

Figure 5

From: Distinct processing of tone offset in two primary auditory cortices

Figure 5

Offset responses in AAF have weak tonotopy, irregular tuning and are present in both fast and regular spiking neurons. (a) Example of distinct tuning receptive fields (TRF) of onset and offset responses of an AAF neuron. (b) Examples of offset TRF of AAF neurons with indication of onset (green) and offset (red) BF. (c,d) Comparison of onset and offset BF of AAF neurons, displayed as a relative distance between electrode shafts. Responses are color-coded to onset (c) or offset (d) BF (correlation between BF and relative distance between electrode’s shaft: onset, ρ = 0.6717, ****p < 0.0001, n = 202; offset, ρ = 0.245, **p = 0.01, n = 150, Spearman correlation). (e,f) Comparison of onset and offset BF for AAF neurons (responses are color-coded to the neuron’s onset BF). (g) Distribution of peak-to-trough times (p2t) of AAF neurons. The red line defines the middle of bimodal distribution (p2t = 0.575). Example of fast (p2t = 0.29; bottom left) and regular (p2t = 1.02; bottom right) spiking unit waveforms. (h) Comparison of onset latency of onset responses as a function of p2t of spike waveforms to 9 kHz PT (top). Responses are color-coded to onset BF. Corresponding average values for FS and RS neurons (bottom). Data represent mean ± SEM. ***p = 0.0003, Mann-Whitney test. (i) Comparison of response onset latency of offset responses as a function of p2t of spike waveforms (top). Corresponding average values for FS and RS neurons (bottom). Data represent mean ± SEM. **p = 0.0019, Mann-Whitney test. (j) Comparison of offset response spike rates as a function of p2t of spike waveforms (top). Corresponding average values for FS and RS neurons (bottom). Data represent mean ± SEM. *p = 0.02, Mann-Whitney test.

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