Figure 4 | Scientific Reports

Figure 4

From: Distinct processing of tone offset in two primary auditory cortices

Figure 4

Offset responses do not emerge in the cortex. (a) Averaged LFP signal (mean ± SD) from L4 A1 (n = 6 animals, 72 recording sites) and AAF (n = 7 animals, 84 recording sites) neurons in response to 9 kHz PTs played at 60 dB SPL with sound duration varying between 50 and 500 ms and ISI between 50 and 2000 ms. The blue shaded bars represent the tone. (b) Comparison of onset and offset peak amplitude of LFP signal in L4 A1 and AAF neurons in response to PTs and HTs with different durations. Data represent mean ± SEM. (c) Offset spike rate (evoked by 9 kHz PTs, duration: 500 ms) in A1 (left) and AAF (right) neurons as a function of recording site depth. Responses are color-coded to the neuron’s onset BF. The gray shaded bars represent L4. (d) Comparison of offset spike rate in L2/3 and L4 of A1 and AAF neurons. Data represent mean ± SEM. (A1: ****p < 0.0001, L2/3 n = 72; L4 n = 88; AAF: p = 0.14, L2/3 n = 69; L4 n = 128, Mann-Whitney test, L4: ****p < 0.0001, A1: n = 88, AAF: n = 128) (e) Offset response latency in A1 (left) and AAF (right) neurons as a function of recording site depth. Responses are color-coded to the neuron’s onset BF. The gray shaded bars represent L4. (f) Comparison of offset spike rate in L2/3 and L4 of A1 and AAF neurons. Data represent means and individual values. (A1: p = 0.09, L2/3 n = 9; L4 n = 31; AAF: p = 0.34, L2/3 n = 52; L4 n = 76, Mann-Whitney test).

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